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Guided Bone Regeneration Via Electrospinning

Guided bone regeneration is a vital component of the recovery process following dental surgery

and various implant-related procedures. This technique improves a patient’s recovery by

strategically placing physical barrier membranes to surround the recovering area in question.

The properties of these barriers allow them to prevent the migration of incorrect cell tissues to

the injury site -- which, if left unattended, can slow the recovery process and introduce

complications for the patient. To avoid this, these membrane barriers ‘guide’ the recovery

process by blocking out cells that should not be at the injury site, resulting in a recovery process

that is both faster and leads to better end results for the patient.

Current barrier membranes available on the market are mainly non-resorbable into the body,

meaning that they must be surgically removed after they have been fully used. This creates the

potential for additional soft tissue-related complications to be introduced in the patient after

removal.

Recent advances in electrospinning technology have created a novel solution to address the

problem of surgical barrier membrane removal: resorbable membranes. Recent studies have

concluded that the combination of polymeric matrices created from PCL and Bioglasses with

bisphosphonate drugs such as ibandronate and alendronate have resulted in increased rates of

bone regeneration compared to the use of solely bioglass. This development greatly increases

the potential for resorbable membranes to be used on patients in the near future because it has

overcome the inconvenient solubility of bisphosphonate drugs when paired with biodegradable

polymers. This will allow this class of drugs for bone regeneration to be paired with bioerodible


electrospun polymers, which had previously proven to be a difficult task. The increased rate of

bone formation shown with the use of this technology gives it a promising potential to improve

the recovery processes of patients post oral surgery -- such as root canal regeneration -- and in

patients suffering from bone injuries.


References:


Berton, F., Porrelli, D., Di Lenarda, R., & Turco, G. (2019). A critical review on the production of

electrospun nanofibres for guided bone regeneration in oral surgery. Nanomaterials,

10(1), 16. https://doi.org/10.3390/nano10010016

Terzopoulou, Z., Baciu, D., Gounari, E., Steriotis, T., Charalambopoulou, G., Tzetzis, D., &

Bikiaris, D. (2019). Composite membranes of poly(ε-caprolactone) with

bisphosphonate-loaded bioactive glasses for potential bone tissue engineering

applications. Molecules, 24(17), 3067. https://doi.org/10.3390/molecules24173067